ASPN, Human (His-SUMO)

ASPN protein acts as a negative regulator in periodontal ligament (PDL) differentiation and mineralization, preventing ossification and maintaining homeostasis of the tooth support system. It inhibits BMP2-induced cell differentiation by blocking the binding of BMP2 to BMPR1B, thereby preventing BMP-dependent activation of SMAD proteins. ASPN Protein, Human (His-SUMO) is the recombinant human-derived ASPN protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ASPN Protein, Human (His-SUMO) is 348 a.a., with molecular weight of 55-60 kDa.

DMEDTDDDDD DDDDDDDDDE DNSLFPTREP RSHFFPFDLF PMCPFGCQCY SRVVHCSDLG LTSVPTNIPF DTRMLDLQNN KIKEIKENDF KGLTSLYGLI LNNNKLTKIH PKAFLTTKKL RRLYLSHNQL SEIPLNLPKS LAELRIHENK VKKIQKDTFK GMNALHVLEM SANPLDNNGI EPGAFEGVTV FHIRIAEAKL TSVPKGLPPT LLELHLDYNK ISTVELEDFK RYKELQRLGL GNNKITDIEN GSLANIPRVR EIHLENNKLK KIPSGLPELK YLQIIFLHSN SIARVGVNDF CPTVPKMKKS LYSAISLFNN PVKYWEMQPA TFRCVLSRMS VQLGNFGM