CZC24832
CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC50=27 nM) with apparent dissociation constants (Kdapp) of 19 nM.
Product Specifications
CAS Number
1159824-67-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/CZC24832.html
Purity
99.07
Solubility
DMSO : ≥ 53 mg/mL
Smiles
FC1=CC(C2=CC(S(=O)(NC(C)(C)C)=O)=CN=C2)=CN3C1=NC(N)=N3
Molecular Formula
C15H17FN6O2S
Molecular Weight
364.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Bergamini G, et al. A selective inhibitor reveals PI3Kγ dependence of T (H) 17 cell differentiation. Nat Chem Biol. 2012 Apr 29;8 (6) :576-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kβ; PI3Kγ; PI3Kδ
Available Sizes
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