Hyaluronidase, Bovine testes

Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection[1][2][3][4][5][6].

Product Specifications

CAS Number

[37326-33-3]

Product Name Alternative

Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/hyaluronidase.html

Purity

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Hyaluronidase,Bovinetestes]

Molecular Weight

55000 (average)

Precautions

H302, H315, H319, H335

References & Citations

[1]Vartanian AJ, et al. Injected hyaluronidase reduces restylane-mediated cutaneous augmentation. Arch Facial Plast Surg. 2005 Jul-Aug;7 (4) :231-7.|[2]Brandon E, et al. The Use of Hyaluronidase in Cosmetic Dermatology: A Review of the Literature. J Clin Investigat Dermatol. 2015;3 (2) : 7.|[3]Apaza Ticona L, et al. Rubus urticifolius Compounds with Antioxidant Activity, and Inhibition Potential against Tyrosinase, Melanin, Hyaluronidase, Elastase, and Collagenase[J]. Pharmaceuticals (Basel) . 2024 Jul 13;17 (7) :937.|[4]Jung H. Hyaluronidase: An overview of its properties, applications, and side effects[J]. Arch Plast Surg. 2020 Jul;47 (4) :297-300.|[5]Lee W, et al. Comparative Effectiveness of Different Interventions of Perivascular Hyaluronidase[J]. Plast Reconstr Surg. 2020 Apr;145 (4) :957-964.|[6]Wang M, et al. Comparison of Intra-arterial and Subcutaneous Testicular Hyaluronidase Injection Treatments and the Vascular Complications of Hyaluronic Acid Filler[J]. Dermatol Surg. 2017 Feb;43 (2) :246-254.|[7] Kim DW, et al. Vascular complications of hyaluronic acid fillers and the role of hyaluronidase in management. J Plast Reconstr Aesthet Surg. 2011 Dec;64 (12) :1590-5. |[8]Gong H, et al. Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy. Nano Lett. 2016 Apr 13;16 (4) :2512-21.