What is the catalog number for Senktide?

The catalog number for Senktide is HY-P0187.

What sizes are available for Senktide?

Senktide is available in the following size(s): 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does Senktide come in?

Senktide is available in 6 different pack sizes.

Is Senktide in stock?

Senktide is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Senktide?

Senktide is manufactured by QuantiMol.

What is the estimated delivery time for Senktide?

Estimated delivery time for Senktide is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Senktide?

The safety data sheet for Senktide is available here: http://file.medchemexpress.com/batch_PDF/HY-P0187/Senktide-SDS-MedChemExpress.pdf.

Senktide

Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50=0.5-3 nM) . Senktide less potently agonizes the NK1 receptor (EC50=35 µM) . Senktide is promising for research of neurological disease[1][2][3][4][5].

Product Specifications

CAS Number

106128-89-6

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Senktide.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C)[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC1=CC=CC=C1)[C@@H](NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)CC2=CC=CC=C2

Molecular Formula

C40H55N7O11S

Molecular Weight

841.97

References & Citations

[1]Nordquist RE, et al. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600 (1-3) :87-92.|[2]Keegan KD, et al. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitiveneurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105 (1) :3-5.|[3]Byk G, et al. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J Med Chem. 1996 Aug 2;39 (16) :3174-8.|[4]Sarau HM, et al. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther. 1997 Jun;281 (3) :1303-11.|[5]Harrison T, et al. High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template. Bioorg Med Chem Lett. 1998 Jun 2;8 (11) :1343-8.