1-Methyl-2-undecyl-4 (1H) -quinolone

1-Methyl-2-undecyl-4 (1H) -quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B) . 1-Methyl-2-undecyl-4 (1H) -quinolone shows a selective inhibition of MAO-B activity with the IC50 and Ki values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4 (1H) -quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS[1][2].

Product Specifications

CAS Number

[59443-02-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Monoamine Oxidase

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-methyl-2-undecyl-4-1h-quinolone.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(CCCCCCCCCCC)N(C)C2=C1C=CC=C2

Molecular Formula

C21H31NO

Molecular Weight

313.48

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Toshiya K, et al. Isolation and Structure Elucidation of Three Quinolone|[2]Lee MK, et al. 1-methyl-2-undecyl-4 (1H) -quinolone as an irreversible and selective inhibitor of type B monoamine oxidase. Chem Pharm Bull (Tokyo) . 2003;51 (4) :409-411.