SF-C5-TPP

SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM>[1].

Product Specifications

UNSPSC

12352005

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sf-c5-tpp.html

Solubility

10 mM in DMSO

Smiles

N#C/C(C#N)=C(CCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)\C4=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C4.[Br-]

Molecular Formula

C41H46BrN2OP

Molecular Weight

693.69

References & Citations

[1]Kirsanov R S, et al. Synthesis of Triphenylphosphonium-Linked Derivative of 3, 5-Di tert-butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler. ACS Omega. 2024.