GPR52 agonist-1

GPR52 agonist-1 is a potent, orally active and blood-brain barrier (BBB) penetrant GPR52 agonist with an pEC50 value of 7.53. GPR52 agonist-1 affects cAMP accumulation through direct interaction with GPR52. GPR52 agonist-1 can significantly suppress Methamphetamine-induced hyperactivity in mice. Antipsychotic activity[1].

Product Specifications

CAS Number

[1207965-40-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GPR52

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gpr52-agonist-1.html

Purity

99.76

Solubility

DMSO : ≥ 100 mg/mL

Smiles

COCCNC(C1=CC(C2=C3SC(CC4=CC(Cl)=CC(F)=C4)=CC3=CC=C2)=CC=C1)=O

Molecular Formula

C25H21ClFNO2S

Molecular Weight

453.96

Precautions

H315, H319, H335

References & Citations

[1]Setoh M, et al. Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52. J Med Chem. 2014 Jun 26;57 (12) :5226-37.