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Tolfenpyrad

Tolfenpyrad is an insecticide approved for marketing in Japan in 2002.

Product Specifications

CAS Number

129558-76-5

UNSPSC

12352005

Hazard Statement

H302+H332

Target

Bacterial; Insecticide; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Tolfenpyrad.html

Concentration

10mM

Purity

98.86

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

O=C(C1=C(Cl)C(CC)=NN1C)NCC2=CC=C(OC3=CC=C(C)C=C3)C=C2

Molecular Formula

C21H22ClN3O2

Molecular Weight

383.87

Precautions

H302+H332

References & Citations

[1]Yamaguchi K, et al. Analysis of tolfenpyrad and its metabolites in plasma in a tolfenpyrad poisoning case. J Anal Toxicol. 2012 Sep;36 (7) :529-37.|[2]Khan MA, et al. Lethal and behavioral effects of selected novel pesticides on adults of Trichogramma pretiosum (Hymenoptera: Trichogrammatidae) . Pest Manag Sci. 2015 Dec;71 (12) :1640-8.|[3]Clarke A, et al. Tolfenpyrad displays Francisella-targeted antibiotic activity that requires an oxidative stress response regulator for sensitivity. Microbiol Spectr. 2023 Dec 12;11 (6) :e0271323.|[4]Preston S, et al. Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm. Int J Parasitol Drugs Drug Resist. 2016 Dec;6 (3) :329-334.|[5]Chi W, et al. The influence of tolfenpyrad on fitness, development, and reproduction in parents and offspring of Coccinella septempunctata. Ecotoxicol Environ Saf. 2021 Mar 1;210:111875.|[6]Hikiji W, et al. Acute fatal poisoning with Tolfenpyrad. J Forensic Leg Med. 2013 Nov;20 (8) :962-4.|[7]Jiang X, et al. Combination of biotransformation and metabolomics reveals tolfenpyrad-induced hepatocytotoxicity. Sci Total Environ. 2024 Nov 15;951:175320.|[8]Preston S, et al. 1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity. J Med Chem. 2021 Jan 14;64 (1) :840-844.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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