Barakol
Product Specifications
UNSPSC Description
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects[1][2][3].
Target Antigen
Apoptosis; Bcl-2 Family; MMP; Reactive Oxygen Species
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/barakol.html
Smiles
OC1=CC2=C3C(OC(C)=CC(OC(C)=C2)3O)=C1
Molecular Weight
232.23
References & Citations
[1]Thongsaard W, et al. Barakol: a potential anxiolytic extracted from Cassia siamea. Pharmacol Biochem Behav. 1996 Mar;53(3):753-8. |[2]Wongsawatkul O, et al. Effects of barakol from Cassia siamea on neuroblastoma SH-SY5Y cell line: A potential combined therapy with doxorubicin. Heliyon. 2024 Jan 19;10(3):e24694. |[3]Wongtongtair S, et al. Barakol-induced apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. J Ethnopharmacol. 2011 Sep 2;137(2):971-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-167825/Barakol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-167825/
Clinical Information
No Development Reported
CAS Number
24506-68-1
Curated Selection
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