Barakol

Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142) . Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects[1][2][3].

Product Specifications

CAS Number

[24506-68-1]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; MMP; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/barakol.html

Smiles

OC1=CC2=C3C(OC(C)=CC(OC(C)=C2)3O)=C1

Molecular Formula

C13H12O4

Molecular Weight

232.23

References & Citations

[1]Thongsaard W, et al. Barakol: a potential anxiolytic extracted from Cassia siamea. Pharmacol Biochem Behav. 1996 Mar;53 (3) :753-8. |[2]Wongsawatkul O, et al. Effects of barakol from Cassia siamea on neuroblastoma SH-SY5Y cell line: A potential combined therapy with doxorubicin. Heliyon. 2024 Jan 19;10 (3) :e24694. |[3]Wongtongtair S, et al. Barakol-induced apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. J Ethnopharmacol. 2011 Sep 2;137 (2) :971-8.