Dioxybenzone

Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study[1][2][3].

Product Specifications

CAS Number

[131-53-3]

Product Name Alternative

Benzophenone-8; UV-24

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Dioxybenzone.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

Smiles

O=C(C1=CC=C(OC)C=C1O)C2=CC=CC=C2O

Molecular Formula

C14H12O4

Molecular Weight

244.24

Precautions

H315, H319, H335

References & Citations

[1]Rao GS, et al. Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water. Anticancer Res. 2013 Jun;33 (6) :2535-40.|[2]Zhan T, et al. Transcriptome aberration in mice uterus associated with steroid hormone response and inflammation induced by dioxybenzone and its metabolites. Environ Pollut. 2021 Oct 1;286:117294.|[3]Sherwood VF, et al. Altered UV absorbance and cytotoxicity of chlorinated sunscreen agents. Cutan Ocul Toxicol. 2012 Dec;31 (4) :273-9.