P, p'-DDD
P, p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p, p'-DDT. p, p'-DDD is an agonist at estrogen receptor α (ERα) and ERβ. p, p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p, p'-DDD stimulates cell proliferation in SKBR3 cells. p, p'-DDD activates the AP-1 transcription factor. p, p'-DDD decreases sleep times of barbiturates and steroids in rats[1][2][3][4].
Product Specifications
CAS Number
72-54-8
Product Name Alternative
4,4'-DDD; p, p'-Dichlorodiphenyl dichloroethane
UNSPSC
12352005
Hazard Statement
H301, H312, H351, H410
Target
Apoptosis; Drug Metabolite; Insecticide; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p-p-ddd.html
Concentration
10mM
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(Cl)C(C1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2
Molecular Formula
C14H10Cl4
Molecular Weight
320.04
Precautions
H301, H312, H351, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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