KRASG12C IN-12
KRASG12C IN-12 (compound-1) is a KRASG12C inhibitor. KRASG12C IN-12 (compound-1) can form a ternary complex with intracellular CYPA and the activated KRASG12C mutant[1].
Product Specifications
CAS Number
2093328-45-9
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krasg12c-in-12.html
Smiles
O=C(N1N[C@@H](CCC1)C(OC)=O)[C@@H](NC([C@H](C(C)C)NC(CCCSSC2=CC=CC=N2)=O)=O)CC3=CC(O)=CC=C3
Molecular Formula
C29H39N5O6S2
Molecular Weight
617.78
References & Citations
[1]Christopher J Schulze, et al. Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science. 2023 Aug 18;381 (6659) :794-799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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