PI3Kα-IN-9

PI3Kα-IN-9 (compound 27) is a selective, long-acting and oral active PI3Kα inhibitor with IC50 values of 4.4, 128, 146 and 153 nM for PI3Kα, PI3Kγ, PI3Kδ and PI3Kβ, respectively. PI3Kα-IN-9 has antiproliferative activity and induces apoptosis. PI3Kα-IN-9 can be used for cancer research[1].

Product Specifications

CAS Number

[2715287-67-3]

UNSPSC

12352005

Target

Apoptosis; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3kα-in-9.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

NC1=NC2=CC(C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)=CC=C2O1

Molecular Formula

C18H21N7O3

Molecular Weight

383.40

References & Citations

[1]Hou Y, et, al. Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer. J Med Chem. 2022 Jul 14.