PD 169316

PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71.

Product Specifications

CAS Number

[152121-53-4]

UNSPSC

12352005

Hazard Statement

H301, H315, H318, H335

Target

Autophagy; Enterovirus; p38 MAPK

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-169316.html

Purity

98.60

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1C2=C(C3=CC=NC=C3)NC(C4=CC=C([N+]([O-])=O)C=C4)=N2

Molecular Formula

C20H13FN4O2

Molecular Weight

360.34

Precautions

H301, H315, H318, H335

References & Citations

[1]Fu Y, et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310 (2) :391-7.|[2]Hu W, et al. Suppression of Nestin reveals a critical role for p38-EGFR pathway in neural progenitor cell proliferation. Oncotarget. 2016 Dec 27;7 (52) :87052-87063.|[3]Kummer JL, et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1997 Aug 15;272 (33) :20490-4.|[4]Khan JA, et al. p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization. Mol Endocrinol. 2011 Oct;25 (10) :1710-24.|[5]Zhang Z, et al. PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71. Virology. 2017 Aug;508:150-158.