Manganese (salen) chloride

Manganese (salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese (salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

Product Specifications

CAS Number

[53177-12-1]

Product Name Alternative

EUK-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/manganese-salen-chloride.html

Purity

97.38

Solubility

DMSO : 8.33 mg/mL (ultrasonic)

Smiles

[Cl-][Mn+3]123[O-]C4=C(C=[N]1CC[N]2=CC5=C([O-]3)C=CC=C5)C=CC=C4

Molecular Formula

C16H14ClMnN2O2

Molecular Weight

356.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275 (2) :798-806.|[2]Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93 (6) :2312-6.|[3]Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48 (4) :824-32.