YVAD-CHO
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM) . YVAD-CHO inhibits mature IL-1β production. YVAD-CHO partially delays motoneurone death in lesioned facial nerve mice[1][2].
Product Specifications
CAS Number
153604-27-4
UNSPSC
12352209
Target
Caspase; Interleukin Related
Type
Peptides
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/yvad-cho.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C=O)=O)=O)[C@H](CC1=CC=C(C=C1)O)N
Molecular Formula
C21H30N4O7
Molecular Weight
450.49
References & Citations
[1]de Bilbao F, Dubois-Dauphin M. Acute application of an interleukin-1 beta-converting enzyme-specific inhibitor delays axotomy-induced motoneurone death. Neuroreport. 1996 Nov 25;7 (18) :3051-4.|[2]Laliberte RE, et al. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem. 1999 Dec 24;274 (52) :36944-51.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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