NVS-PAK1-C
NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM) [1].
Product Specifications
CAS Number
[2250019-95-3]
UNSPSC
12352005
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nvs-pak1-c.html
Purity
99.2
Solubility
10 mM in DMSO|DMSO : ≥ 50mg/mL
Smiles
O=C(N1C[C@@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C4=CC=C(Cl)C=C42)CC1)N(C)C
Molecular Formula
C22H23ClF3N5O
Molecular Weight
465.90
References & Citations
[1]NVS-PAK1-1 A Chemical Probe For PAK1
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1; PAK2
Available Sizes
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