c-Myc Recombinant Rabbit Monoclonal Antibody [JE01-20]
Selected Variant
HA722895
Size: 100 µL
Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). Myc is thought to function by upregulating transcript elongation of actively transcribed genes through the recruitment of transcriptional elongation factors. It can also act as a transcriptional repressor. By binding Miz-1 transcription factor and displacing the p300 co-activator, it inhibits expression of Miz-1 target genes. In addition, myc has a direct role in the control of DNA replication.This activity could contribute to DNA amplification in cancer cells.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Myc proto-oncogene protein Class E basic helix-loop-helix protein 39 (bHLHe39) Proto-oncogene c-Myc Transcription factor p64
Swiss Prot
P01106 Human, P01108 Mouse, P09416 Rat
Cellular Locus
Nucleus, nucleoplasm, nucleolus, Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Synthetic peptide.
Isotype
IgG
Clone
JE01-20
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell
Positive Control
HeLa cell lysate, A549 cell lysate, HepG2 cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, C6 cell lysate, COS-1 cell lysate, HeLa, NIH/3T3.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 50 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Price
Frequently Asked Questions
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