c-Myc Recombinant Rabbit Monoclonal Antibody [JE01-20]
Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). Myc is thought to function by upregulating transcript elongation of actively transcribed genes through the recruitment of transcriptional elongation factors. It can also act as a transcriptional repressor. By binding Miz-1 transcription factor and displacing the p300 co-activator, it inhibits expression of Miz-1 target genes. In addition, myc has a direct role in the control of DNA replication.This activity could contribute to DNA amplification in cancer cells.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Myc proto-oncogene protein Class E basic helix-loop-helix protein 39 (bHLHe39) Proto-oncogene c-Myc Transcription factor p64
Swiss Prot
P01106 Human, P01108 Mouse, P09416 Rat
Cellular Locus
Nucleus, nucleoplasm, nucleolus, Cytoplasm.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Monkey
Immunogen
Synthetic peptide.
Isotype
IgG
Clone
JE01-20
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell
Positive Control
HeLa cell lysate, A549 cell lysate, HepG2 cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, C6 cell lysate, COS-1 cell lysate, HeLa, NIH/3T3.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 50 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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