Hymeglusin
Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM) . Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].
Product Specifications
CAS Number
29066-42-0
Product Name Alternative
F-244; 1233A; L-659699
UNSPSC
12352005
Target
Antibiotic; Dengue Virus; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hymeglusin.html
Purity
99.30
Solubility
DMSO : 25 mg/mL
Smiles
O=C(O)/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@H]([C@H]1CO)OC1=O
Molecular Formula
C18H28O5
Molecular Weight
324.41
References & Citations
[1]Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389 (1-2) :18-19.|[2] Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84 (21) :7488-92.|[3] Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636 (1) :22-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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