Hymeglusin

Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM) . Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].

Product Specifications

CAS Number

[29066-42-0]

Product Name Alternative

F-244; 1233A; L-659699

UNSPSC

12352005

Target

Antibiotic; Dengue Virus; Flavivirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hymeglusin.html

Purity

99.30

Solubility

DMSO : 25 mg/mL

Smiles

O=C(O)/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@H]([C@H]1CO)OC1=O

Molecular Formula

C18H28O5

Molecular Weight

324.41

References & Citations

[1]Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389 (1-2) :18-19.|[2] Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84 (21) :7488-92.|[3] Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636 (1) :22-8.