Indazole

Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].

Product Specifications

CAS Number

271-44-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSK-3; LRRK2; Monoamine Oxidase

Type

Reference compound

Related Pathways

Autophagy; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/indazole.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C12=CC=CC=C1NN=C2

Molecular Formula

C7H6N2

Molecular Weight

118.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Shang C, et al. The Anticancer Activity of Indazole Compounds: A Mini Review. Curr Top Med Chem. 2021;21 (5) :363-376. |[2]Pal D, et al. Importance of Indazole against Neurological Disorders. Curr Top Med Chem. 2022;22 (14) :1136-1151. |[3]Uppulapu SK, et al. Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives. Curr Top Med Chem. 2022;22 (14) :1177-1188. |[4]Saha S, et al. Indazole Derivatives Effective against Gastrointestinal Diseases. Curr Top Med Chem. 2022;22 (14) :1189-1214. |[5]Qin J, et al. Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anticancer Agents Med Chem. 2021;21 (7) :839-860.