Guangxitoxin-1E

<strong>Guangxitoxin-1E</strong> <strong>Catalog number:</strong> MDP0794 <strong>CAS Number: </strong>1241836-78-1 <strong>Sequence: </strong>Glu-Gly-Glu-Cys-Gly-Gly-Phe-Trp-Trp-Lys-Cys-Gly-Ser-Gly-Lys-Pro-Ala-Cys-Cys-Pro-Lys-Tyr-Val-Cys-Ser-Pro-Lys-Trp-Gly-Leu-Cys-Asn-Phe-Pro-Met-Pro (Reported disulfide bonds between Cys4-Cys19, Cys11-Cys24, and Cys18-Cys31) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 3948.4 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Hönigsperger C, Nigro MJ, Storm JF. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E J Physiol. 2017 Feb 1;595(3):739-757. 2: Yang CT, Lu GL, Hsu SF, MacDonald I, Chiou LC, Hung SY, Chen YH. Paeonol promotes hippocampal synaptic transmission: The role of the Kv2.1 potassium channel Eur J Pharmacol. 2018 May 15;827:227-237. 3: Kow LM, Kandel H, Kilinc M, Daniels MA, Magarinos AM, Jiang CS, Pfaff DW. Potassium channels and the development of arousal-relevant action potential trains in primary hindbrain neurons Brain Res. 2021 Oct 1;1768:147574. 4: Newkirk GS, Guan D, Dembrow N, Armstrong WE, Foehring RC, Spain WJ. Kv2.1 Potassium Channels Regulate Repetitive Burst Firing in Extratelencephalic Neocortical Pyramidal Neurons Cereb Cortex. 2022 Feb 19;32(5):1055-1076. 5: Liu PW, Bean BP. Kv2 channel regulation of action potential repolarization and firing patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons J Neurosci. 2014 Apr 2;34(14):4991-5002. 6: Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4789-96. 7: Chao RY, Cheng CH, Wu SN, Chen PC. Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration J Neurochem. 2018 Feb;144(4):483-497. 8: Yang CT, Leung YM, Hsu SF, MacDonald I, Wang ML, Lin JG, Hung SY, Chen YH. A comparison of the delayed outward potassium current between the nucleus ambiguus and hippocampus: sensitivity to paeonol Eur J Pharmacol. 2016 Aug 5;784:49-60. 9: Ratliff KS, Petrov A, Eiermann GJ, Deng Q, Green MD, Kaczorowski GJ, McManus OB, Herrington J. An automated electrophysiology serum shift assay for K(V) channels Assay Drug Dev Technol. 2008 Apr;6(2):243-53. <a href="https://pubmed.ncbi.nlm.nih.gov/23161216">10: Li XN, Herrington J, Petrov A, Ge L, Eiermann G, Xiong Y, Jensen MV, Hohmeier HE, Newgard CB, Garcia ML, Wagner M, Zhang BB, Thornberry NA, Howard AD, Kaczorowski GJ, Zhou YP. The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets J Pharmacol Exp Ther. 2013 Feb;344(2):407-16. </a> <br><strong>Products Related to Guangxitoxin-1E can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>