Dibromomaleimide-C5-COOH
Dibromomaleimide-C5-COOH (DBM-C5-COOH) is a bifunctional dibromomaleimide (DBM) linker. Dibromomaleimide-C5-COOH can be used to connect MMAF and to synthesize ADC[1].
Product Specifications
CAS Number
[1443214-97-8]
Product Name Alternative
DBM-C5-COOH
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dibromomaleimide-c5-cooh.html
Purity
99.40
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(CCCCCN1C(C(Br)=C(C1=O)Br)=O)O
Molecular Formula
C10H11Br2NO4
Molecular Weight
369.01
References & Citations
[1]Behrens CR, et al. Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs. Mol Pharm. 2015 Nov 2;12 (11) :3986-98.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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