Nampt-IN-10 (TFA)
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs[1].
Product Specifications
CAS Number
[2567724-20-1]
UNSPSC
12352211
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nampt-in-10-tfa.html
Purity
98.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C=C1NC([C@@H]2[C@@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C27H28FN5O2.xC2HF3O2
References & Citations
[1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9 (8) :838-842.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
KLM6332 1x 96 Well
GENLISA™ Mouse Secretory Leukocyte Peptidase Inhibitor (SLPI) ELISA
Sign In for Pricing
View Details 
GTR15346088 1 Vial
Lentiviral human RAD51AP1 shRNA (UAS) - Lentiviral human RAD51AP1 shRNA (UAS) (25)
Sign In for Pricing
View Details 
031907-AP 200 µL
ANKS1B, ID (ANKS1B, Ankyrin repeat and sterile alpha motif domain-containing protein 1B, Amyloid-beta protein intracellular domain-associated protein 1, E2A-PBX1-associated protein) (AP) discontinued
Sign In for Pricing
View Details