GSK251
GSK251 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode.
Product Specifications
CAS Number
2125968-05-8
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk251.html
Purity
99.88
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC(N2CCOCC2)=CN=C1OC)(NC3=CC(C4=CC=C(CN5CCN(C(C)C)CC5)C=C4F)=NC=C3)=O
Molecular Formula
C29H37FN6O4S
Molecular Weight
584.71
References & Citations
[1]Down K, et al. Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode. J Med Chem. 2021 Sep 23;64 (18) :13780-13792.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSH031633 100 µg
Recombinant Human IL-20RA/IL-20R1 Protein (His Tag)
Sign In for Pricing
View Details 
