GSK251
GSK251 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode.
Product Specifications
CAS Number
2125968-05-8
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk251.html
Purity
99.88
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC(N2CCOCC2)=CN=C1OC)(NC3=CC(C4=CC=C(CN5CCN(C(C)C)CC5)C=C4F)=NC=C3)=O
Molecular Formula
C29H37FN6O4S
Molecular Weight
584.71
References & Citations
[1]Down K, et al. Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode. J Med Chem. 2021 Sep 23;64 (18) :13780-13792.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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