Protein kinase inhibitor 1
Protein kinase inhibitor 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
Product Specifications
CAS Number
[1365986-44-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protein-kinase-inhibitor-1.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(NC/1=O)SC1=C\C2=CNC(C(C3=CC=C(N4CCNCC4)N=C3)=C2)=O
Molecular Formula
C18H17N5O3S
Molecular Weight
383.42
Precautions
H315, H319, H335
References & Citations
[1]Miduturu CV, et al. High-throughput kinase profiling: a more efficient approach toward the discovery of new kinaseinhibitors. Chem Biol. 2011 Jul 29;18 (7) :868-79.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Biochem Mol Toxicol. 2021 May;35 (5) :e22737.|Biol Direct. 2025 Jun 19;20 (1) :71.|EBioMedicine. 2021 Dec:74:103713.|EBioMedicine. 2022 Nov:85:104274.
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