Lupanine

Lupanine (D-Lupanine) is a natural ketonic derivative of Sparteine (HY-W008350) with a ganglioplegic activity. Lupanine shows binding affinity for nicotinic receptor with a Ki value of 500 nM[1].

Product Specifications

CAS Number

[550-90-3]

Product Name Alternative

D-Lupanine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lupanine.html

Purity

98.04

Solubility

DMSO : 50 mg/mL

Smiles

O=C1N2[C@]([C@](C3)([H])CN(CCCC4)[C@]4([H])[C@]3([H])C2)([H])CCC1

Molecular Formula

C15H24N2O

Molecular Weight

248.36

Precautions

H302, H315, H319, H335

References & Citations

[1]K Yovo, et al. Comparative pharmacological study of sparteine and its ketonic derivative lupanine from seeds of Lupinus albus. Planta Med. 1984 Oct;50 (5) :420-4.|[2]Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.