Lupanine
Lupanine (D-Lupanine) is a natural ketonic derivative of Sparteine with a ganglioplegic activity. Lupanine shows binding affinity for nicotinic receptor with a Ki value of 500 nM[1].
Product Specifications
CAS Number
550-90-3
Product Name Alternative
D-Lupanine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lupanine.html
Purity
98.04
Solubility
DMSO : 50 mg/mL
Smiles
O=C1N2[C@]([C@](C3)([H])CN(CCCC4)[C@]4([H])[C@]3([H])C2)([H])CCC1
Molecular Formula
C15H24N2O
Molecular Weight
248.36
Precautions
H302, H315, H319, H335
References & Citations
[1]K Yovo, et al. Comparative pharmacological study of sparteine and its ketonic derivative lupanine from seeds of Lupinus albus. Planta Med. 1984 Oct;50 (5) :420-4.|[2]Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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