VP3.15 (dihydrobromide)
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE) 7- glycogen synthase kinase (GSK) 3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS) [1].
Product Specifications
CAS Number
[1281681-33-1]
UNSPSC
12352005
Target
GSK-3; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vp3-15-dihydrobromide.html
Purity
98.01
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
[H]Br.[H]Br.N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1
Molecular Formula
C20H24Br2N4OS
Molecular Weight
528.30
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE7
Citation 01
J Biol Chem. 2025 Jan 27:108244.|Pennsylvania State University. 2025.|J Biol Chem. 2023 Aug;299 (8) :104991.
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