ERAP2-IN-1
ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC50 of 27 μM and model peptide hydrolysis with an IC50 of 44 μM[1].
Product Specifications
CAS Number
2420551-38-6
UNSPSC
12352005
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/erap2-in-1.html
Purity
98.86
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(OC)C(S(=O)(NC2=CC=C(C(F)(F)F)C=C2N3CCCCC3)=O)=C1
Molecular Formula
C20H21F3N2O5S
Molecular Weight
458.45
References & Citations
[1]Arya R, et al. Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition. ACS Chem Biol. 2022 Jun 29.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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