PB131

PB131 is a selective and brain-permeable HDAC6 inhibitor with high binding affinity (IC50: 1.8 nM) . PB131 has potent anti-inflammatory activity. PB131 can be used for research of inflammation, especially neuroinflammation[1].

Product Specifications

CAS Number

[2924425-63-6]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pb131.html

Purity

99.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(F)=C(C=C1)CN2CCCC3=CC=CN=C32)NO

Molecular Formula

C16H16FN3O2

Molecular Weight

301.32

References & Citations

[1]Liu G, et al. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. Eur J Med Chem. 2023 Jun 5;254:115327.