MC-Val-Ala-PAB-PNP
MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
1639939-40-4
UNSPSC
12352203
Hazard Statement
H315, H319
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-val-ala-pab-pnp.html
Purity
99.51
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O
Molecular Formula
C32H37N5O10
Molecular Weight
651.66
Precautions
H315, H319
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Protease Cleavable Linker
Available Sizes
Frequently Asked Questions
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