AGI-41998

AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. AGI-41998 exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 22 nM and 34 nM. AGI-41998 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-41998 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer[1].

Product Specifications

CAS Number

[2377492-26-5]

UNSPSC

12352005

Target

Methionine Adenosyltransferase (MAT)

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/agi-41998.html

Purity

99.94

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=C(Br)C=C2)=C3N=C(NCC(F)(F)F)N=CC3=CN1C4=CC=C(OC)C=C4

Molecular Formula

C22H16BrF3N4O2

Molecular Weight

505.29

References & Citations

[1]Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65 (6) :4600-4615.