Z-VAD
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2) . Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation[1].
Product Specifications
CAS Number
[162852-62-2]
UNSPSC
12352209
Target
Apoptosis; Autophagy; Caspase; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/z-vad.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C[C@@H](C(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
Molecular Formula
C20H27N3O8
Molecular Weight
437.44
References & Citations
[1]Luigi Moretti, et al. Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor. Mol Cancer Ther. 2009 May;8 (5) :1270-9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 6; Caspase 7; Caspase 8; Caspase 9
Available Sizes
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