α-Conotoxin LtIA

Product Specifications

UNSPSC Description

α-Conotoxin LtIA is an α3β2 nAChR blocker (IC50=9.8 nM), that can be obtained from Conus litteratus venom. Alpha-Conotoxin LtIA can be used in the study of neurological diseases (such as Parkinson's disease, pain)[1].

Target Antigen

nAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H]1C(N[C@H](C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H]3CC(C)C)=O)=O)=O)=O)=O)=O)=O)CSSC1)=O)C)=O)=O)=O)=O)CSSC[C@@H](C(N)=O)NC3=O)=O)CN

Molecular Weight

1600.87

References & Citations

[1]Luo S, et al. Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J Biol Chem. 2010 Apr 16;285(16):12355-66.