Evixapodlin
Evixapodlin (GS-4224) is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. Evixapodlin has anticancer and antiviral functions[1].
Product Specifications
CAS Number
[2374856-75-2]
Product Name Alternative
GS-4224; PD-1/PD-L1-IN 7
UNSPSC
12352005
Target
HBV; PD-1/PD-L1
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-7.html
Concentration
10mM
Purity
98.14
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=C(C(C=CC=C2C(C=N3)=NC(OC)=C3CNC[C@H](CC4)NC4=O)=C2Cl)C=CC=C1C(C=N5)=NC(OC)=C5CNC[C@H](CC6)NC6=O
Molecular Formula
C34H36Cl2N8O4
Molecular Weight
691.61
References & Citations
[1]Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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