Cefoxitin (sodium)

Cefoxitin sodium (MK-306) is a cephalosporin-class antibiotic. Cefoxitin sodium is highly stable against β-Lactamase (HY-P2998) . Cefoxitin sodium has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria[1][2][3].

Product Specifications

CAS Number

[33564-30-6]

Product Name Alternative

MK-306

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Cefoxitin-sodium.html

Concentration

10mM

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(N12)=C(COC(N)=O)CS[C@]2([H])[C@@](NC(CC3=CC=CS3)=O)(OC)C1=O)O[Na]

Molecular Formula

C16H16N3NaO7S2

Molecular Weight

449.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Cavalli Z, et al. Prolonged Cefoxitin Infusion Using Mobile Elastomeric Infusors In Outpatients With Bone And Joint Infection. J Bone Jt Infect. 2018 Sep 7;3 (4) :182-186.|[2]R N Brogden, et al. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979 Jan;17 (1) :1-37.|[3]Venkata Raveendra Pothineni, et al. In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. Drug Des Devel Ther. 2018; 12: 2915–2921.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

J Antimicrob Chemother. 2020 Jul 1;75 (7) :1850-1858.|Antimicrob Agents Chemother. 2025 May 23:e0024925.|bioRxiv. 2025 Jun 19.|Diagn Microbiol Infect Dis. 2025 Nov 4;114 (2) :117181.|Infect Drug Resist. 2025 Oct 4:18:5239-5247.|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|J Clin Microbiol. 2025 Aug 20:e0084125.|Microbiol Spectr. 2025 May 19:e0307424.|Nat Commun. 2022 Mar 2;13 (1) :1116.|Nat Commun. 2023 Mar 22;14 (1) :1594.|Nat Microbiol. 2023 Mar;8 (3) :410-423.