Etofylline
Product Specifications
UNSPSC Description
Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos[1][2][3].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Etofylline.html
Purity
99.72
Solubility
DMSO : 25 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C)N(C)C2=C(N(CCO)C=N2)C1=O
Molecular Weight
224.22
References & Citations
[1]Wattanaporn Tavipatana, et al.Etophylline and theophylline pharmacokinetics when administered concomitantly in rabbits. International Journal of Pharmaceutics. Volume 30, Issues 2–3|[2]Chandrakantsing V Pardeshi ,et al. Mannose-anchored N,N,N-trimethyl chitosan nanoparticles for pulmonary administration of etofylline. Int J Biol Macromol. 2020 Dec 15;165(Pt A):445-459.|[3]Ram Manohar Basnet, et al. Zebrafish Embryo as an In Vivo Model for Behavioral and Pharmacological Characterization of Methylxanthine Drugs. Int J Mol Sci. 2017 Mar 9;18(3):596.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1209/Etofylline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1209/Etofylline-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
519-37-9
Available Sizes
Curated Selection
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