Obicetrapib

TA-8995 is a new and selective cholesteryl ester transfer protein (CETP) inhibitor.

Product Specifications

CAS Number

[866399-87-3]

Product Name Alternative

TA-8995; DEZ-001

UNSPSC

12352005

Target

CETP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/obicetrapib.html

Purity

98.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=CC(C(F)(F)F)=CC(CN(C2=NC=C(OCCCC(O)=O)C=N2)[C@@H]3C4=CC(C(F)(F)F)=CC=C4N([C@@H](C3)CC)C(OCC)=O)=C1

Molecular Formula

C32H31F9N4O5

Molecular Weight

722.60

References & Citations

[1]Ford J , et al. Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Br J Clin Pharmacol. 2014 Sep;78 (3) :498-508.|[2]Hovingh GK, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP) : a randomised, double-blind, placebo-controlled phase 2 trial. Lancet. 2015 Aug 1;386 (9992) :452-460.