Obicetrapib
TA-8995 is a new and selective cholesteryl ester transfer protein (CETP) inhibitor.
Product Specifications
CAS Number
866399-87-3
Product Name Alternative
TA-8995; DEZ-001
UNSPSC
12352005
Target
CETP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/obicetrapib.html
Purity
98.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC(C(F)(F)F)=CC(CN(C2=NC=C(OCCCC(O)=O)C=N2)[C@@H]3C4=CC(C(F)(F)F)=CC=C4N([C@@H](C3)CC)C(OCC)=O)=C1
Molecular Formula
C32H31F9N4O5
Molecular Weight
722.60
References & Citations
[1]Ford J , et al. Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Br J Clin Pharmacol. 2014 Sep;78 (3) :498-508.|[2]Hovingh GK, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP) : a randomised, double-blind, placebo-controlled phase 2 trial. Lancet. 2015 Aug 1;386 (9992) :452-460.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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