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PROTAC K-Ras Degrader-4

PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway[1]. (Pink: ligand for target protein pan-KRAS degrader 1 (HY-162960) ; Black: linker (HY-159790) ; Blue: ligand for E3 ligase VHL (HY-W998248) )

Product Specifications

CAS Number

[2938169-99-2]

UNSPSC

12352005

Target

PROTACs; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-k-ras-degrader-4.html

Purity

99.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]1(C2=NC(C3=NC(N4[C@H](CN(CCC4)CCCCOC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=C5)C)=NC=C3)=NO2)C9=C(CCC1)SC(N)=C9C#N

Molecular Formula

C50H60N12O6S2

Molecular Weight

989.22

References & Citations

[1]Popow J, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024 Sep 20;385 (6715) :1338-1347.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

Available Sizes

Curated Selection

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