Sulindac sulfide

Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.

Product Specifications

CAS Number

[49627-27-2]

Product Name Alternative

Cis-Sulindac sulfide

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Drug Metabolite; γ-secretase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Sulindac_sulfide.html

Purity

99.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CC(C1=C/2C=CC(F)=C1)=C(C)C2=C\C3=CC=C(SC)C=C3

Molecular Formula

C20H17FO2S

Molecular Weight

340.41

Precautions

H302, H312, H332

References & Citations

[1]Takahashi Y, et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem. 2003 May 16;278 (20) :18664-70.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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