Sulindac sulfide
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
Product Specifications
CAS Number
49627-27-2
Product Name Alternative
Cis-Sulindac sulfide
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Drug Metabolite; γ-secretase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Sulindac_sulfide.html
Purity
99.07
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CC(C1=C/2C=CC(F)=C1)=C(C)C2=C\C3=CC=C(SC)C=C3
Molecular Formula
C20H17FO2S
Molecular Weight
340.41
Precautions
H302, H312, H332
References & Citations
[1]Takahashi Y, et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem. 2003 May 16;278 (20) :18664-70.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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