NDT 9513727
NDT 9513727 is a potent, selective, orally active and competitive inverse agonist of the human C5aR (C5a receptor), with an IC50 of 11.6 nM. NDT 9513727 can be used for the research of human inflammatory diseases[1].
Product Specifications
CAS Number
439571-48-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ndt-9513727.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 57 mg/mL (ultrasonic; warming)
Smiles
CCCCN1C(CN(CC2=CC=C(OCO3)C3=C2)CC4=CC=C(OCO5)C5=C4)=C(C6=CC=CC=C6)N=C1C7=CC=CC=C7
Molecular Formula
C36H35N3O4
Molecular Weight
573.68
Precautions
H302, H315, H319
References & Citations
[1]Robbin M Brodbeck, et al. Identification and characterization of NDT 9513727 [N, N-bis (1,3-benzodioxol-5-ylmethyl) -1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist. J Pharmacol Exp Ther. 2008 Dec;327 (3) :898-909.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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