NDT 9513727

NDT 9513727 is a potent, selective, orally active and competitive inverse agonist of the human C5aR (C5a receptor), with an IC50 of 11.6 nM. NDT 9513727 can be used for the research of human inflammatory diseases[1].

Product Specifications

CAS Number

[439571-48-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Complement System

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ndt-9513727.html

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 57 mg/mL (ultrasonic; warming)

Smiles

CCCCN1C(CN(CC2=CC=C(OCO3)C3=C2)CC4=CC=C(OCO5)C5=C4)=C(C6=CC=CC=C6)N=C1C7=CC=CC=C7

Molecular Formula

C36H35N3O4

Molecular Weight

573.68

Precautions

H302, H315, H319

References & Citations

[1]Robbin M Brodbeck, et al. Identification and characterization of NDT 9513727 [N, N-bis (1,3-benzodioxol-5-ylmethyl) -1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist. J Pharmacol Exp Ther. 2008 Dec;327 (3) :898-909.