SEL24-B489

SEL24-B489 is a potent, type I, orally active, dual PIM and FLT3-ITD inhibitor, with Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively[1].

Product Specifications

CAS Number

[1616359-00-2]

UNSPSC

12352005

Hazard Statement

H301, H373, H412

Target

Apoptosis; FLT3; Pim

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sel24-b489.html

Purity

99.02

Solubility

DMSO : 25 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

CC(N1C(C2CCNCC2)=NC3=C([N+]([O-])=O)C(Br)=C(Br)C=C31)C

Molecular Formula

C15H18Br2N4O2

Molecular Weight

446.14

Precautions

H301, H373, H412

References & Citations

[1]Wojciech Czardybon, A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia. Oncotarget. 2018 Mar 30;9 (24) :16917-16931.|[2]Ewa Jablonska, et al. A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity. Blood (2015) 126 (23) : 706.