OTS514

OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells[1]. OTS514 induces cell cycle arrest and apoptosis[2].

Product Specifications

CAS Number

[1338540-63-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; TOPK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/OTS514.html

Purity

99.77

Solubility

DMSO : 12 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC2=C(C(C3=CC=C([C@@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4

Molecular Formula

C21H20N2O2S

Molecular Weight

364.46

Precautions

H302

References & Citations

[1]Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6 (259) :259ra145.|[2]Stefka AT, et al. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models. Cancer Med. 2020 Jan;9 (1) :324-334.