KRpep-2d (TFA)

KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].

Product Specifications

UNSPSC

12352209

Target

Ras

Type

Peptides

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/krpep-2d-tfa.html

Purity

98.11

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@@H](CSSC[C@@H]1NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)C(C)C)=O)=O)CC(O)=O)=O)CC4=CC=C(C=C4)O)=O)CO)=O)([H])[C@@H](C)CC)=O)CC5=CC=C(C=C5)O)=O)CC(C)C)=O)([H])CCC2.OC(C(F)(F)F)=O

Molecular Formula

C110H183F3N44O27S2

Molecular Weight

2675.03

References & Citations

[1]Niida A, et al. Investigation of the structural requirements of K-Ras (G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27 (12) :2757-2761.