ASP7663

ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions[1][2].

Product Specifications

CAS Number

[1190217-35-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/asp7663.html

Concentration

10mM

Purity

99.16

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C1C(N(CC(C)C)C2=C/1C=CC=C2F)=O

Molecular Formula

C14H14FNO3

Molecular Weight

263.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Ryosuke Kojima, et al. Effects of Novel TRPA1 Receptor Agonist ASP7663 in Models of Drug-Induced Constipation and Visceral Pain. Eur J Pharmacol. 2014 Jan 15;723:288-93.|[2]Yao Lu, et al. Transient Receptor Potential Ankyrin 1 Activation Within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016 Dec;125 (6) :1171-1180.