ASP7663
ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions[1][2].
Product Specifications
CAS Number
1190217-35-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/asp7663.html
Concentration
10mM
Purity
99.16
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C1C(N(CC(C)C)C2=C/1C=CC=C2F)=O
Molecular Formula
C14H14FNO3
Molecular Weight
263.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Ryosuke Kojima, et al. Effects of Novel TRPA1 Receptor Agonist ASP7663 in Models of Drug-Induced Constipation and Visceral Pain. Eur J Pharmacol. 2014 Jan 15;723:288-93.|[2]Yao Lu, et al. Transient Receptor Potential Ankyrin 1 Activation Within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016 Dec;125 (6) :1171-1180.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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