PROTAC EED degrader-1
PROTAC EED degrader-1 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9.02. PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.17) targeting the EED subunit[1].
Product Specifications
CAS Number
[2639882-72-5]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Histone Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-eed-degrader-1.html
Purity
98.27
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
Molecular Formula
C55H60FN11O8S
Molecular Weight
1054.20
Precautions
H302, H312, H332
References & Citations
[1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456 (19) 30362-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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