PROTAC EED degrader-1
Product Specifications
UNSPSC Description
PROTAC EED degrader-1 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9.02. PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.17) targeting the EED subunit[1].
Target Antigen
Histone Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-eed-degrader-1.html
Purity
98.27
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=C(C)N=C(CCC(NCCOC5=CC=C(OCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O)C=C5)=O)C=C4)C9=NN=CN39
Molecular Weight
1054.20
References & Citations
[1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130614/PROTAC-EED-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130614/PROTAC-EED-degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2639882-72-5
Available Sizes
Curated Selection
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